张华北(北师大教授)

编辑:列表君时间:2024-01-03 01:51:25来源:列表在线网

张华北(北师大教授)的个人简介

张华北，博士, 北京师范大学教授，博士生导师?。现任放射性药物教育部重点实验室副主任，中国核学会核化学与放射化学学分会副主任委员，中国化学会核化学与放射化学专业委员会副主任，北京核学会核医学和分子影像专委会副主任委员，中国核学会同位素分会常务理事，中国同位素与辐射行业协会专家咨询委员会委员，核化学与放射化学杂志副主编，同位素杂志副主编。

个人简介

张华北，博士, 北京师范大学教授，博士生导师。现任放射性药物教育部重点实验室副主任，中国核学会核化学与放射化学学分会副主任委员，中国化学会核化学与放射化学专业委员会副主任，北京核学会核医学和分子影像专委会副主任委员，中国核学会同位素分会常务理事，中国同位素与辐射行业协会专家咨询委员会委员，核化学与放射化学杂志副主编，同位素杂志副主编。

张华北教授是放射性药物教育部重点实验室主要学术带头人之一，长期从事药物设计、合成、标记和生物性质评价。正式发表论文90多篇(除少数几篇之外均为第一作者或通讯作者), 其中许多文章发表在J. Med. Chem.，Curr. Med. Chem.，Curr. ?Pharm. ?Des.等国外重要杂志上，授权国家科技发明专利多项。主持国家16个重大科技专项重大新药创制项目、国家科技支撑课题以及国家自然科学基金多项，曾获洪堡基金在德国波斯特尔医学和药物研究所做高级访问学者。

张华北教授在中国科学院组织的放射化学咨询报告中担任放射性药物部分的负责人和主要撰稿人，该报告得到温家宝总理和刘延东副总理的重要批示，主要负责起草的关于加强放射性药物研发的建议得到了我国34位两院院士的签名支持。张华北教授还是国家自然科学基金委组织的无机化学学科前沿与展望一书放射化学部分的负责人和主要撰稿人。在第八届中日双边放射性药物会议和第十二届全国放射性药物与标记化合物会议担任大会组委会执行主席。

研究领域

1) 计算机辅助药物分子设计

2）药物合成

3）放射性标记

4）生物评价

主持的部分项目

1、主持国家16个重大科技专项重大新药创制专项（项目名称：用于重大疾病诊治的创新放射性药物研制；项目编号：2014ZX09507007，经费：1401.06万元：起止时间：2014.1-2017.12)

2、主持国家自然科学基金项目（项目名称：新型神经型烟碱乙酰胆碱α7受体显像剂的设计与合成；项目编号： 21371026；?经费：85元万；?起止时间：2014.1-2017.12)

3、国家科技支撑课题（课题名称：脑受体等五种放射性药物研究；课题编号：2014BAA03B03，经费：363万元）

4、主持横向课题（项目名称：锕系与镧系元素配位化学计算, 经费：10万元；起止时间:2011.1-2014.12）

5、主持横向课题（项目名称：放射性药物影像学研究（二期），?经费：5万元；起止时间:2014.3-2014.6）

发表的部分文章

1. Zeng HH， Zhang HB*，Synthesis and biological evaluation of fatty acids conjugates bearing cyclopentadienyl-donors incorporated [(99m)Tc/Re(CO)3](+) for myocardical imaging， Eur. J. Med.?Chem.2014，24(72):10-7

2. YuHJ,?Fang Y,?Lu X, ?Liu?YJ, ?Zhang HB*，Combined 3D-QSAR, Molecular Docking, Molecular Dynamics Simulation, and Binding Free Energy Calculation Studies on the 5-Hydroxy-2H-Pyridazin-3-One Derivatives as HCV NS5B Polymerase Inhibitors, CHEMICAL BIOLOGY & DRUG DESIGN?，2014, 83:?89-105

3. Zeng HH, Zhao LZ, Hu SY, Liu YJ, Yu HJ, Chen N, Zhang HB*.,Synthesis, characterization and biodistribution of new fatty acids conjugates bearing N,N,N-donors incorporated [(99m)Tc/Re(CO)(3)](+), ?Dalton Trans.2013,?42(8):2894-901.

4. Lu X, Zhao LZ, Xue T, Zhang HB*, Technetium-99m- Arg-Arg-Leu(g2), a modified peptide probe targeted to neovascularization in molecular tumor imaging, J BUON.2013 ;18(4):1074-81.

5. Hu S, Yu H, Liu Y, Xue T, Zhang H.?Insight into the binding model of new antagonists of kappa receptor using docking and molecular dynamics simulation.?J Mol Model.2013，19(8):3087-94.

6. Zeng HH, Zhang HB, Wu XX, Preliminary studies of a novel cyclopentadienyl tricarbonyl technetium-99m fatty acid derivative for myocardical imaging, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS?，2013，56(1): 1-5.?

7. Liu YJ,?Yu HJ,?Zhao, LZ, Zhang HB*, Design and synthesis of new agents for neuronal nicotinic acetylcholine receptor (nAChRs) imaging,?NUCLEAR MEDICINE AND BIOLOGY,2013,?40(1): 126-134 ?

8. Liu YJ, Yu HJ, Zhao, LZ, Zhang HB*,Design and synthesis of new agents for neuronal nicotinic acetylcholine receptor (nAChRs) imaging, NUCLEAR MEDICINE AND BIOLOGY 40(1): 126-134,2013.

9. Zhao, Lingzhou; Liu, Yongjuan; Hu, Shiyuan; ZhangHB* , 3D-QSAR study of Chk1 kinase inhibitors based on docking, JOURNAL OF MOLECULAR MODELING,?2012,18(8): 3669-3694

10. Chen Na; Liu Chunkai; Zhao Lingzhou, Zhang Huabei*, 3D-QSAR study of multi-target-directed AchE inhibitors based on autodocking, MEDICINAL CHEMISTRY RESEARCH, 21(2): 245-256,2012

11．Zeng H, Zhang H, Jang F, Zhao L, Zhang J. Molecular Modeling Studies on Benzimidazole Carboxamide Derivatives as PARP-1 Inhibitors Using 3D-QSAR and Docking, Chem Biol Drug Des.?2011,78(3):333-52.

12．Zeng Huahui; Zhang Huabei，Domestic Advances in Brain, Heart, and Tumor Radioactive Diagnosis Drugs，PROGRESS IN CHEMISTRY，2011，23（7）: 1485-1492

13．Yang Yang; Zhu Lin; Chen Xiangji，Binding research on flavones as ligands of beta-amyloid aggregates by fluorescence and their 3D-QSAR, docking studies， JOURNAL OF MOLECULAR GRAPHICS & MODELLING2010，29( 4): 538-545

14．Yang Y, Zhu L, Cui MC, Tang RK, Zhang HB* ?Preparation of classical Re/Tc-99m(CO)(3)(+) and novel Tc-99m(CO)(2)(NO)(2+) cores complexed with flavonol derivatives and their binding characteristics for A beta((1-40)) aggregates，BIOORGANIC & MEDICINAL CHEMISTRY LETTERS，2010， 20（ 17）: 5337-5344

15．Zeng HH, Zhang HB*，Combined 3D-QSAR modeling and molecular docking study on 1,4-dihydroindeno[1,2-c]pyrazoles as VEGFR-2 kinase inhibitors， JOURNAL OF MOLECULAR GRAPHICS & MODELLING，2010, 29（1）， 54-71， 2010

16．Cao R, Mi N, Zhang H*. 3D-QSAR study of c-Src kinase inhibitors based on docking.

J Mol Model. 2010，16(2):361-75.

17．Yang Y, Zhang JX, Zhu L, Zhang H* Synthesis, Novel Crystal Structure, and beta-Amyloid Binding Property of Re(I) (tricarbonyl) EHIDA Analogue Bioinorg Chem Appl. 2009:702730.

18．Cao R, Mi N, Zhang H*.,3D-QSAR study of c-Src kinase inhibitors based on docking.J Mol Model. 2010 Feb;16(2):361-75.

19．Yang Y, Zhu L, Zhang HB*. Di-tert-butyl 2,2’-[(2-hydroxyethyl)azanediyl] diacetate ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE ?2009，65（12）3167-U1248.

20．Cao R, Zeng H, Zhang H*.，3D-QSAR studies on a series of inhibitors docked into a new homology model of the DNA-PK receptor.?Curr. ?Pharm. ?Des. 2009; 15(32): 3796-825.

21．Cao HY, Cao R, Zhang HB*, Zheng XF, Gao DB，Non-nucleoside Inhibitors of NS5B Polymerase Binding to Allosteric Sites: 3D- QSAR and Molecular Docking Studies，Curr. Med. Chem., 2008，15: 1462-77.

22．Zhang HB*, Hu SP, Zhang YL. Prediction of distribution of neutral, acidic and basic structurally diverse compounds between blood and brain by the nonlinear methodology. Med Chem. 2008 , 4:170-89.

23． Zhang HB*, Li H, Ma QQ QSAR study of a large set of 3-pyridyl ethers analogues，Journal of Molecular Graphics and Modelling, 2007, ?26: 226-235.

24． Cao HY, Zhang HB*，Zheng XF, Gao DB，3D QSAR studies on a series of potent and high selective inhibitors for three kinases of RTK family，Journal of Molecular Graphics and Modelling, 2007, 26:236-245.

25. Zhang HB*, Zhang YL, ?Convenient Nonlinear Model for Predicting the Tissue/Blood Partition Coefficients of Seven Human Tissues of Neutral, Acidic and Basic Structural-Diverse Compounds, J. Med. Chem., 2006，49:, 5815-5829.

26. Zhou JM, Zhou JH, Zhang HB, et al. Fluoro-substitution effects in deoxyfluoro-D-glucose derivatives: random conformational search and quantum chemical calculation?, CARBOHYDRATE RESEARCH, 2006, 341: 2224-2232.

27. Zhang HB*, A QSAR Study of the Brain/Blood Partition Coefficients on the Basis of ?pKa Values, QSAR & combinary chemistry, 2006, 25:, 15-24.

28. Zhang HB*, Li H, Liu CP，CoMFA, CoMSIA and Molecular Hologram QSAR Studies of Novel Neuronal nAChRs Ligands u2013 Open Ring Analogues of 3-pyridyl Ether，J. Chem. Inf. model. 2005, 45: 440-448.

29. Zhang HB*, Ye HH, ?Zhang YL , et al.Synthesis, biodistribution and QSAR studies of five Tc-99m labeled novel N3S pseudo-peptide complexes， Med. Chem. Res. 2005, 14: 40-56.

30. Zhang HB*, A new approach for the tissue-blood partition coefficients of neutral and ionized compounds, J. Chem. Inf. model. 2005, 45:121-127.

部分发明专利

张华北，u2002赵凌舟；u2002卢霞；u2002薛甜，一种具有粘着斑激酶抑制作用的嘧啶类化合物及其制备方法和应用，专利号：2012105919329，授权公告日：2015-4-29

张华北；曾华辉；u2002于海静，新型锝-99m标记的高级脂肪酸衍生物，专利号：2011101492546，授权公告日：2014-06-25

张华北(北师大教授)